An estimation of efficiency of assisted reproductive technologies is at violations of homoeostasis

Abstract

DOI: 10.52705/2788-6190-2023-04-13
УДК 618.177-089.888.11:616.43/.45-093/.098-058

The objective. Men and women have a study of features of homoeostasis from sterile matrimonial
pair, plugged in the program of assisted reproductive technologies.
Materials and methods. In the real work these inspections are presented 250 men and women
in age from 24 to 46 years (35,1±in 4,3), that consist in sterile marriage. Duration of infertility in
marriage varied from 2 to 16 years (6,5±in 2,1). In the etiopathogenetic structure of infertility a
female factor appeared in 30% cases, masculine –- in 10% cases, while combinations of the
united violations of reproductive function were diagnosed in most matrimonial pair (60%).
To beginning of cycle of assisted reproductive technologies the unfolded inspection of partners
was conducted: collection somatic, obstetric-gynaecological and to andrological anamnesis,
ultrasonic research, clinical-and-laboratory and biochemical researches.
Results. At the estimation of concentration of testosterone in blood of men was found out his
decrease for men from the group of assisted reproductive technologies as compared to persons
from the group of control (accordingly 14,9±0,8 nmol/l and 18,8±0,6 nmol/l; p<0,05). Thus
among patients from pathospermia there is considerable part of persons with the low products
of testosterone (61,5%) and with rejections in the products of gonadotropins (39,5%). However,
absence of clinical signs of hypogonadism for the patients of the program of assisted reproductive
technologies, specifies on that androgenic insufficiency for them, probably, carries relative
character on a background, as a rule, to the stored gonadotropic function.
The analysis of hormonal function of ovaries rotined that certain differences are in the functional
state of the reproductive system of patients and practically healthy women which are expressed
in the reliable decline of concentration of estradiol at 1,5 time in a periovulatory period, and also
in diminishing of products of progesterone in the luteal phase of cycle.
Conclusion. The results of the conducted endocrinology and microbiological researches in matrimonial
pair testify to deeper, than it it is accepted to count, violation of reproductive function of and men, and
women, plugged in the program of assisted reproductive technologies. Thus the representatives of
matrimonial pair have violation of the neuroendocrine adjusting the basic nosotropic links of violation
of reproductive function and microbiocenosis of the genitourinary system.
The got results must be taken into account at development of algorithm of increase of efficiency
of assisted reproductive technologies.