Features of pathogeny of hyperplastic processes of uterus

Authors

  • Yuliya Strakhovetska Medical center «Ashera», Kharkiv.

Keywords:

hyperplastic processes of uterus, pathogeny, pathogens

Abstract

DOI: 10.52705/2788-6190-2024-02-14
УДК 618.14-002718-007.61-092-02:616.9

The objective: establishment of role infectious to the pathogen in development of hyperplastic
processes of uterus.
Materials and methods. 250 women which were up-diffused on five groups were inspected.
Plugging criteria are in research: presence of the combined hyperplastic processes of uterus -
two and more for a disease (endometrial hyperplasia, uterine fibroids and adenomyosis), verified
morphologically, fertile age (25–45 years).
On the basis of clinical motion of disease, information of genital status and pathomorphological
conclusion the followings groups were formed: I a group was made by 50 women with the
hyperplastic process of endometrium and uterine fibroids, II group – 50 women with hyperplastic
process of endometrium and adenomyosisом; III group - 50 patients with combination of three
diseases – adenomyosis, uterine fibroidss and endometrial hyperplasia. Foundation for plugging
in the group of comparison was a presence exceptionally of endometrial hyperplasia (without
combination with uterine fibroids and adenomyosis, IV is a group) (information retrospective
inspection, n = 50). The control V group was made by 50 women from a contingent gynaecological
of healthy (for comparison of immunological indexes).
In the complex of the conducted researches were used clinical, microbiological, echographic,
endocrinology, morphological and statistical methods.
Results. It is set pathomorphological researches of operating biopsies (endometrium, uterine
fibroids and hearths of adenomyosis), that for patients with combination of endometrial
hyperplasia with a uterine fibroids and adenomyosis is the signs of chronic inflammatory
process in tissues of uterus. Infecting of tissues of endometrium and myometrium de bene esse
by pathogenic microorganisms (21,7% women are with the hyperplastic processes of uterus);
staggered by them not only mucus shell but also myocytes (in 26,9% – with uterine fibroids,16,1%
– endometrial hyperplasia, 40% – from adenomyosis). High middle title of Mycoplasma of hominis
6,12±0,19 CFU/ml (from 104 to 109). Correlation of hyperplastic diseases of uterus is with the
stamms of mutants of M. hominis (r=+0,36; p=0,012).
Conclusions. The got results allow to examine infectious pathogens as cofactors of hyperplastic
processes uteruses, nosotropic related to the representatives of flora of lower departments of
genital highway and such which take participating in realization of inflammatory process.

Author Biography

Yuliya Strakhovetska, Medical center «Ashera», Kharkiv.

candidate of medical sciences, doctor obstetrician-gynecologist of medical center «Ashera», Kharkiv.

Published

04.07.2024

How to Cite

1.
Страховецька Ю. Features of pathogeny of hyperplastic processes of uterus. par [Internet]. 2024 Jul. 4 [cited 2024 Jul. 15];4(2):89-94. Available from: http://par.org.ua/index.php/par/article/view/195