Combined aspects of pathogenesis of mammary dysplasia and uterine fibroids

Abstract

DOI: 10.52705/2788-6190-2024-04.1-16
УДК 6187173-036:618.19-007.17+618.14-006,36-092

The objective: the women of perimenopausal age have a study of the combined aspects of pathogenesis of mammary dysplasia in combination with a uterine fibroids.
Materials and methods. For the decision of the put purpose the formed group which consists of 50 patients with mammary dysplasia (25 women with the diffuse form of mammary dysplasia and 25 women are with the localized forms of mammary dysplasia) and uterine fibroids. In addition, realizable analysis of hospital and ambulatory maps of this contingent of patients charts.
By us was the developed program of researches, which foresees a conduct clinical-and-statistical analysis; to the complex of hormonal researches (determination of sexual steroids: estradiol, progesterone, testosterone; gonadotropic hormones (follicle-stimulating hormone, luteinizing hormone, prolactin); thyrotropic hormone and hormones of thyroid (triiodo-thyronine, thyroxine); roentgenologic research of mammary glands; soonographic researches of genitalia and mammary glands; cytological and histological methods with application of biopsy of puncture and mathematical processing.
Results. The basic moments of pathogenesis of mammary dysplasia and uterine fibroids is clinical-and-anamnestic information, and also change of correlation of levels of hypothalamopituitary hormones, ovarian hormones as absolute or relative hyperestrogenism, more expressed for patients with the localized forms of mammary dysplasia. Violations of normal menstrual cycle appear in 76% patients, dysbiotic processes of genitalia - in 46% women with mammary dysplasia.
Conclusions. The got results it must draw on at development of complex of diagnostic and prognostic measures.