Ways of increase of efficiency of assisted reproductive technologies are at the combined forms of infertility taking into account immunological factors
Keywords:
the combined forms of infertility, assisted reproductive technologies, efficiency, are immunological factorsAbstract
DOI: 10.52705/2788-6190-2024-04.1-18
УДК 618.177-089.888.11-097:612.017.1
The objective: to learn the role of cytokines in efficiency of gonadotropic stimulation of ovaries in the loop of assisted reproductive technologies and his results at the matrimonial pair of reproductive age with the combined forms of infertility.
Materials and methods. 70 matrimonial pair of reproductive age, which made the followings groups, were inspected: basic (n=30), comparison (n=30) and control (n=10). Plugging criteria in a basic group were: age 25–38 years; infertility (endocrine, pipe peritoneal, combined); program of assisted reproductive technologies; stimulation of ovaries by preparations of gonadotropins; an offensive of pregnancy is after the real program of assisted reproductive technologies (visualization of ovum at ultrasonic research in 3 weeks after transference of embryos). In the complex of the conducted researches were included clinical, echographic, endocrinology, morphological, statistical and immunological methods.
Results. Findings testify that strengthening of secretion in the ovary of pro-inflammatory cytokines can be one of mechanisms of unfavorable influence of stimulation of ovaries of gonadotropins on an oocyte. It is presently foreseen that stimulation of ovaries, its modes influence on «quality» of oocyte, potency of him to the impregnation and rates of early development of embryo. A negative role high concentrations can play in blood of estradiol, and also pharmacological preparations which are used during stimulation
of ovaries (gonadotropins, agonists and antagonists of gonadotropin-releasing hormone). The got results were confirmed by present fundamental pictures that co-operation between an oocyte and somatic cages of ovary is critical for normal motion of oogenesis, impregnation and early development of embryo.
Conclusions. The results of the conducted researches testify that to informing clinical-andanamnestic and hormonal factors which determine the result of cycle of assisted reproductive technologies for the patients of reproductive age with the combined forms of infertility, take: age of the patient; body mass index; presence pipe peritoneal factor of infertility; a level of free testosterone is in blood; a table of contents of progesterone is in blood on 20–22 days of menstrual cycle, and also determination in the follicle liquid of ovaries of cytokines.
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