Pregnancy outcomes in internally displaced women and the possibilities of correcting inflammation­ associated complications: results of a prospective study

Abstract

DOI: 10.52705/2788-6190-2026-03-2
УДК 618.3-06:616.9:616-092.19

Objective: To evaluate the effect of complex therapy on pregnancy outcomes and inflammation-associated complications in internally displaced women.
Materials and Methods:A prospective controlled study included 84 pregnant internally displaced women with chronic inflammatory conditions of the genital tract. Participants were enrolled at 12–22 weeks of gestation and divided into two groups: Group I (n=42) received standard antenatal care, while Group II (n=42) received standard care combined with complex therapy, including micronized progesterone, omega-3 fatty acids, and local vaginal treatment. Statistical significance was set at p<0.05.
Results: Complex therapy was associated with a significant reduction in inflammation-associated complications. The incidence of threatened preterm labor and premature rupture of membranes decreased by approximately 1.8–2.4-fold, placental dysfunction nearly twofold, and preterm birth more than twofold. These effects were accompanied by reduced systemic inflammation, reflected by lower C-reactive protein levels, and improved vaginal microbiota. Neonatal outcomes were more favorable, including higher birth weight and improved Apgar scores.
Conclusions: Complex therapy targeting inflammatory, hormonal, and local infectious mechanisms reduces pregnancy complications and improves perinatal outcomes in internally displaced women.