Features of pathogeny of anaemia of pregnant with violations in a pubertal period

Abstract

DOI: 10.52705/2788-6190-2021-4-3
УДК 618.3-06:616.155.194:612.392.4

The objective: study of role of whey ferritin in pathogeny of anaemic syndrome for expectant mothers with violations in a pubertal period.
Materials and methods. For the decision of the put purpose in research were included 335 pregnant. All patients parted on two categories: a basic group is 275 women which suffered an anaemic syndrome in I, II and the III trimesters of pregnancy. They were up-diffused on a І group – 185 women, sufferings iron-scarce anaemia in I, II and the III trimesters pregnancies at which the sharp are not fixed or chronic infectious-inflammatory diseases, both to and in the period of the real pregnancy. Anaemia for such women we de bene esse designated as actual iron-scarce anaemia and group II – 90 women with anaemia in the III trimester of pregnancy which developed on a background sharp or chronic infectious-inflammatory pathology. Anaemic syndrome for such patients we de bene esse designated as anaemia of inflammatory diseases. A control group was made by 60 women with the physiology flow of pregnancy and normal indexes of conntrration haemoglobin, numbers of red corpuscles in peripheral blood and exchange of iron, at which chronic infectious and autoimmune diseases are not fixed in anamnesis.
Results. Concentration of haemoglobin in the I trimester for patients with actual iron deficient anaemia which developed in the III trimester, there was authentically higher, than for the patients of control group: 119,8±1,9 g/l against 118,8±2,7 g/l accordingly. Opposite, the concentration of whey ferritin in a control group in all trimesters appeared for certain higher, than for pregnant with anaemia in the different terms of gestation. It confirms that at prognostication of risk of development of anaemia more correct is oriented not on the initial level of haemoglobin, but on the concentration of whey ferritin. The coefficient of linear correlation of the investigated indexes makes in the I trimester of pregnancy +0,63, in the II trimester +0,79, and in trimester +0,77. Essence of logarithmic dependence consists in that at the higher values of whey ferritin haemoglobin goes down not so substantially, as it is marked at the low levels of whey ferritin.
Conclusion. The results of the conducted researches testify to the substantial role of whey ferritin in pathogeny of anaemic syndrome for expectant mothers in all trimesters of gestation. The set features of pathogeny of anaemic syndrome must be taken into account at development of complex of diagnostic and treatment-and-prophylactic measures.