The state of local immunity is at inflammatory diseases of cervix and vagina

Abstract

DOI: 10.52705/2788-6190-2022-04-5
УДК 618.15-002-022.1-097:612.112.3

The objective: to estimate the state of local immunity at the inflammatory diseases of cervix and
vagina.

Materials and methods. 9 type groups were selected: I –generally healthy (42 women), II –
carriage of candida (45 women), III – bacterial vaginosis (112 women), IV is a heterospecific
vulvovaginitis (107 women), V – acute vulvovaginal candidiasis (61 women), VI – chronic
vulvovaginal candidiasis (76 women), VII – bacterial vaginosis + candida infection (71 woman),
VIII – heterospecific vulvovaginitis + candida infection (84 women), IX – bacterial vaginosis +
heterospecific vulvovaginitis (63 women). After distributing of patients on groups the conducted is
deep immunological researches.
Results. The expressed changes in quantitative and high-quality composition of phagocytes found
out at a candida infection. On a background prevailing of neutrophilis the pool of macrophages, which matter very much in absorption of large objects which cages of fungus are, is increased in
vaginal separated. Disfunction and inhibition of phagocytic reactions conduces to reproduction
and invasion of fungus, forming of chronic forms.
An amount and activity of neutrophilis differed at the different forms of disease. Acute candidal
vulvovaginitis was characterized by the preservation of their number and functional activity, and at a
chronic form, in spite of increase of amount, the considerable decline of absorptive power is marked.
It should be noted that such violations conduce not only to long-term persistence of mushrooms but
also to the change of composition of microflora of vagina. Phagocytic reactions at the mixed forms
had some similar parameters: a considerable increase of amount of leucocytes, their disfunction and
increase of fate of macrophages, is at joining of mycotic infection. Such changes can be explained
by not only the action of plenty of antiphagocytic factors of microbal nature but also duration of
infectious process which results in exhaustion of local defense mechanisms.
Conclusions. The results of the conducted researches testify to the substantial role of system and
local phagocytosis at the estimation of the state of factors of defence for patients from infectiously
inflammatory by the diseases of cervix and vagina. The got results must be taken into account at
development of algorithm of diagnostic and treatment-and- prophylactic measures.