TY - JOUR AU - Костюк, Ірина PY - 2023/01/22 Y2 - 2024/03/29 TI - The state of local immunity is at inflammatory diseases of cervix and vagina JF - Perinatology and reproductology: from research to practice JA - par VL - 2 IS - 4 SE - Articles DO - UR - http://par.org.ua/index.php/par/article/view/95 SP - 50-56 AB - <p><strong>DOI: <a href="https://doi.org/10.52705/2788-6190-2022-04-5" target="_blank" rel="noopener">10.52705/2788-6190-2022-04-5</a></strong><br><strong>УДК 618.15-002-022.1-097:612.112.3</strong></p><p><strong>The objective</strong>: to estimate the state of local immunity at the inflammatory diseases of cervix and<br>vagina.</p><p><strong>Materials and methods</strong>. 9 type groups were selected: I –generally healthy (42 women), II –<br>carriage of candida (45 women), III – bacterial vaginosis (112 women), IV is a heterospecific<br>vulvovaginitis (107 women), V – acute vulvovaginal candidiasis (61 women), VI – chronic<br>vulvovaginal candidiasis (76 women), VII – bacterial vaginosis + candida infection (71 woman),<br>VIII – heterospecific vulvovaginitis + candida infection (84 women), IX – bacterial vaginosis +<br>heterospecific vulvovaginitis (63 women). After distributing of patients on groups the conducted is<br>deep immunological researches.<br><strong>Results</strong>. The expressed changes in quantitative and high-quality composition of phagocytes found<br>out at a candida infection. On a background prevailing of neutrophilis the pool of macrophages, which matter very much in absorption of large objects which cages of fungus are, is increased in<br>vaginal separated. Disfunction and inhibition of phagocytic reactions conduces to reproduction<br>and invasion of fungus, forming of chronic forms.<br>An amount and activity of neutrophilis differed at the different forms of disease. Acute candidal<br>vulvovaginitis was characterized by the preservation of their number and functional activity, and at a<br>chronic form, in spite of increase of amount, the considerable decline of absorptive power is marked.<br>It should be noted that such violations conduce not only to long-term persistence of mushrooms but<br>also to the change of composition of microflora of vagina. Phagocytic reactions at the mixed forms<br>had some similar parameters: a considerable increase of amount of leucocytes, their disfunction and<br>increase of fate of macrophages, is at joining of mycotic infection. Such changes can be explained<br>by not only the action of plenty of antiphagocytic factors of microbal nature but also duration of<br>infectious process which results in exhaustion of local defense mechanisms.<br><strong>Conclusions</strong>. The results of the conducted researches testify to the substantial role of system and<br>local phagocytosis at the estimation of the state of factors of defence for patients from infectiously<br>inflammatory by the diseases of cervix and vagina. The got results must be taken into account at<br>development of algorithm of diagnostic and treatment-and- prophylactic measures.</p> ER -