Features of forming of intestinal microflora clinical displays of dysbiosis of intestine for children, bear in natural way and by a way caesarean section

Abstract

DOI: 10.52705/2788-6190-2025-4-18
УДК 618.4+618.5-089.888.61-06:616.34-008.87-053.31-08-039

The objective: to estimate the features of forming of intestinal microflora clinical displays of dysbiosis of intestine for children, bear in natural way and by a way caesarean section.
Materials and methods. We analysed clinical symptoms of dysbiosis of intestine in 77 children, bear a way caesarean section, and 72 children, bear in natural way. In addition, we are conduct a bacteriological inspection 72 pair mother-child concerning the clinically expressed forms of dysbiosis for children. To the complex of the conducted researches were included clinical, microbiological, virologic, biochemical and statistical.
Results. Dysbiosis of colon found out for mothers in 76,3%, to the pharynx – in 77,8%, nose – in 55,6% cases. Microecological violations for women, mainly, appeared on a background the chronic diseases of organs of digestion (47,2%) and chronic festering inflammatory processes of different localization: chronic tonsillitis (16,2%), furunculosis (5,6%), disease of the urinary system (20,8%) and others. In 47,2% cases to the mother produced complaint about dysfunction of intestine, mainly in form locks. For every second woman looked after the deficit of indigenous bacteria (mainly bifidobacteria and normal E.Coli), and in 40,3% cases of mother were colonized conditionally pathogenic microflora (S.aureus, Candida sрp. and Clostridium spр.). At comparison of microbal maps of feces of mother and child in any pair it is not discovered complete accordance of composition of intestinal microflora. In 15,3% cases in mothers and child in feces found out identical kinds conditionally pathogenic microflora (S. aureus, Clostridium of difficile, E. coli Hly+). It is discovered that for children, which are reared by mothers which have a deficit of bifidobacteria, – at 2,2 time (RR = 2,2 [95% confidence interval (СI) 1,5; 2,99]), enterococcus – at 3,4 time (RR = 3,4 [95% CI 1,1; 13,2]), lactobacilli at 6,2 time (RR = 6,2 [95% СI 1,8; 20,8]) to have a greater risk a mionectic level of population of these microorganisms, what for children, whose mothers have normal level of population of indigenous flora. It was also discovered that for children which are reared by mothers, colonized S.aureus, at 1,6 time anymore risk of infecting of intestine by this microorganism, what for children, whosesoever mothers are the transmitters of staphylococcus in an intestine (RR = 1,6 [95% СI 1,2; 1,7]). From the different variants of violation of microflora of colon the deficit of bifidoflora and colonization of colon has a high prognostical value of positive result in mothers S.aureus. Authenticity of development of analogical changes of composition of intestinal microflora for a child in the period of the pectoral rearing is 77,8 92,4%.
Conclusions. For children, bear a way caesarean section, characteristic protracted forming of intestinal microflora. In age 2–3 years only in these 25,8% cases children have composition, proper to the generally accepted norm. To 2-years-old age for certain more frequent than for children, bear in natural way, for them mionectic amount of bifidobacteria (42–53,8%) and lactobacilli (17,4– 27,4%), and also associations (31,8–72,5%) and persistence appear conditionally pathogenic microorganisms. To put, bear a way caesarean section, have more expressed clinical symptoms of dysbiosis of intestine and greater risk of development in early age of chronic enterocolitis (RR = 1,5), atopic dermatitis (RR = 2,2), candidosis (RR = 3,4), iron-deficiency anaemia (RR = 2,02), syndrome of neutropenia (RR = 2,9), frequent respirator infections (RR = 2,7), what to put, bear in natural way.