Features of the functional state of pituitary­ovarian and immune system at the proliferative processes of endometrium for women different age

Abstract

DOI: 10.52705/2788-6190-2025-02.2-09
УДК 618.14-007.415:611.664]-06:618.11-002:616.432]-008-039:612.017

The objective: to learn the features of the functional state of pituitary-ovarian and immune system at the proliferative processes of endometrium for women different age.
Materials and methods. Organizational and methodical approach consisted in that the method of continuous selection in research on the study of the state of endometrium included 647 women (basic group) with pathology of mucous membrane of the uterus. From them 138 patients are with the of high quality hyperplastic processes of endometrium, where patients entered with glandular and glandular-cystophorous hyperplasia of endometrium. 509 patients with the morphological variants of shrine of endometrium, that meet more frequent all. 67 women without pathology of endometrium, made the control group of comparison. The laboratory methods of researches were included by biochemical, endocrinological and immunological indexes.
Results. The incurrence of cross-correlation connections between the parameters of immune status digitised by us grows almost three times at the maintainance of predominance of positive connections. It is an indisputable certificate of functional tension of immunity at his specific reactions on a tumour process. Closer, than in control, copulas become among the indexes of all links of immunity: cellular, humoral and phagocytic. The new are in addition, determined cross-correlation copulas which represent close co-operation of links of the immune system in the process of immune antitumor response at the high-differentiated tumours of endometrium are important on principle. For patients with low-grade differentiated adenocarcinoma the separation of work of basic links of the immune system and decline of them is fixed functional possibilities, especially phagocytic link. The amount of intercommunications of immunological indexes for patients with low-grade differentiated adenocarcinoma by comparison to control is megascopic. Pays attention on itself absence of any correlations between the indexes of cellular and humoral links with parameters which characterize functional activity of phagocytes. At the same time, intrasystem correlations of low-grade differentiated adenocarcinoma link make practically a fourth from found out all dependences and represent the presence of the high
functional loading on phagocytosis. However much the level of indexes of this link (phagocytic index, phagocytic number, time of output on the peak of curve of induced) allows to draw conclusion about his high possibilities.
Got information, taking into account the age-old features of indexes, testify to the balanced enough work of the immune system for women without pathology of endometrium and patients with the of high quality hyperplastic processes of endometrium.
Conclusions. It is set that at the nosotropic variant of endometrial cancer activating of cellular link of the immune system, conditioned by hyperestrogenemia is marked; functional activity of phagocytic link for these patients is reduced at keeping possibility of presentation of antigens. At the second variant of disease of possibility of cellular link repressed with development of
disbalance of immunoregulatory subpopulation due to the hypersecretion of stress hormones, and phagocytic – reduced with exhaustion of metabolic backlogs of cages sharp limitation of presentation capabilities. At the first nosotropic variant of endometrial cancer the most expressed influence is on the metabolic processes of hyperestrogenia in default of antiproliferative action
of progesterone, and at the second variant a greater value for proliferation of tumour tissue has combination of hyperinsulinemia with the enhanceable concentration of somatotropin, amino acid which result in stimulation of transport, in the cages of tumour to the increase of synthesis of albumen. Findings must be taken into account at development of algorithm of diagnostic and treatment-andprophylactic measures.