Features of pathogeny of plural hyperplastic processes of organs of the reproductive system

Abstract

DOI: 10.52705/2788-6190-2025-4-09
УДК 618.17/.5-002.18-092-039

The objective: to estimate the features of pathogenesis of plural hyperplastic processes of organs of the reproductive system.
Materials and methods. For the decision of the put purpose 74 women are inspected. To the basic group entered 54 patients with two and by more hyperplastic processes of organs of the reproductive system (uterine fibroids, hyperplasia and endometrial polyps, adenomyosis, external genital endometriosis, fibro-cystic mastopathia). A control group was made by 20 women from ovulatory menstrual cycle, middle duration of 28,4 ± 0,8 day. Except for clinical and echographic methods, for research to the function of ovaries determined maintenance in blood of estradiol on 5–7 day of menstrual cycle, progesterone on 20–24 days of menstrual cycle. Quantitative determination in the whey of blood of insulin-like growth factor-1 was conducted on 5– day of menstrual cycle with the use of solid-phase of immunochemiluminescent method on the automatic analyzers of Immulite and Immulite 1000, Diagnostics Products Corporation (USA). Determination in the whey of blood of epidermal growth factor, transforming growth factor-β1 and vascular endothelial growth factor conducted in both phases of menstrual cycle with the use of sets of Biosourse International, Inc. Human EGF, TGF-βl, VEGF (ELISA) Biosourselnternational (Europe S.A.) on the basis of solid-phase of enzyme-linked immunosorbent assay.
Results. In the real research was not it succeeded to get objective information, indicative on connection of increase of thyroid with content of epidermal growth factor, transforming growth factor-βl, vascular endothelial growth factor and insulin-like growth factor I in blood of the inspected women. However, the vascular endothelial growth factor which is the basic factor of angiogenesis appeared considerably enhanceable in blood of women with the plural hyperplastic processes of organs of the reproductive system, thus in reverse dependence on the level of progesterone. Similar results before in literature did not come into question and correlated with information about the increase of level of vascular endothelial growth factor for women with the polycystic ovary syndrome.
Conclusions. The level of vascular endothelial growth factor in blood of women with the plural hyperplastic processes of organs of the reproductive system (199,1 ± 20,5 pg/ml) for certain exceeds the proper index for healthy women (94,7 ± 7,0 pg/ml), here is reverse dependence of level of vascular endothelial growth factor from content of progesterone in blood. Findings must be taken into account at development of algorithm of diagnostic and treatment-andprophylactic measures.