Optimization of treatment of recurrent diseases of servix is on the stage of pregravid preparation

Abstract

DOI: 10.52705/2788-6190-2024-01-06
УДК 618.146-08

The objective: to promote efficiency of treatment of recurrent background diseases of servix on
the basis of study of basic clinical-and-functional, biochemical, immunological and microbiological
changes, and also improvement of algorithm of treatment-and-prophylactic measures.
Materials and methods. By us it was conducted complex clinical-and-functional and laboratory
inspection 120 women in age 20–40 from recurrent background diseases of servix: ectopia of
servix, leukoplakia and papilloma servix, which developed on a background a urogenital infection.
All patients were up-diffused on four groups depending on in-use medical measures. Were used
clinical, instrumental, microbiological, immunological, cytological and statistical.
Results. For patients with the recurrent background diseases of servix a disbalance is marked
from the side of cellular and humoral immunity, and also decompensated changes of the functional
state of phagocytosis and cytokine status. To our opinion it is conditioned by negative influence
of chronic urogenital infection which is confirmed by high-frequency of semination of sexual ways
pathogenic and de bene esse pathogenic by a microflora.
The got results are a ground for the conducting of specific preparation with the obligatory use
of immunocorrection and sanation of sexual ways. The decision of clinical signs of disease for
all inspected patients was observed during 2–4 weeks from the beginning of treatment and
accompanied by normalization of picture of strokes of scraping material from an urethra, vagina,
cervical channel: diminishing of number of leucocytes, amount of mucus, disappearance of
yeast mycelium, diminishing of number of cocci, shallow sticks, appearance of large number of
lactobacterium. Elimination of pathogenic agent which is set on the basis of polymerase chain
reaction was attained for almost all patients, plugged in an inspection during 6 weeks after the
beginning of treatment which testifies to efficiency of the individually conducted treatment.
Conclusions. The use of the offered algorithm of treatment-and-prophylactic measures
for patients with the recurrent background diseases of servix promotes the less expressed
inflammatory reaction of surrounding tissue, to reduction of term of wound healing, formation of
thin and barely visible scar, complete epitelialization of defect already to the fifth days, to minimum
necrosis of tissue, poorly expressive inflammatory reaction and development of granulation tissue
complete epitelialization of wound in 7–10 days.
The remote results of the offered algorithm of treatment-and-prophylactic measures (to 1 year)
testify to absence of anomalous colposcopic picture, minimum relapse (1 case) at simultaneous
normalization of microbiocenosis of sexual ways and local immunity. It allows to recommend this
method for the wide use in a practical health protection.