Modern aspects of polycystic ovary syndrome

Abstract

DOI: 10.52705/2788-6190-2024-01-10
UDC 618.11-006.2-008.6-053.6-07-08-035

The objective: The girls of pubertal period have an increase of efficiency of treatment of polycystic
ovary syndrome (PCOS) on the basis of study of clinical and echographic and endocrinology
features, and also improvement of algorithm of diagnostic and treatment-and-prophylactic
measures.
Materials and methods. It is conducted clinical-and-laboratory and functional inspection 160
girls of pubertal period, from what 140 were with PCOS. 80 girls were got by the different method (hormonal and unhormonal) of treatment. 20 girls without pathology of ovaries made a control
group. Research methods: clinical, endocrinology, biochemical, morphological, instrumental and
statistical.
Results. For teenagers with PCOS of the use of hormonal correction in the mode 63/7 appeared
effective in 87,5 cases and accompanied by the meaningful braking of the pituitary-ovarian system
diminishing of volume of ovaries (р≤0,01), that at 1,4 time increases the chance of proceeding
in the rhythm of menstruations after abolition of treatment as compared to the mode of the use in
a 21/7 mode (RR=1,4; 95% CI: 1,1–2,1, p=0,05).
The use of hormonal correction in 4 times more frequent causes the proof adjusting of rhythm of
menstruations for girls at the exposure of mixed-caliber type of structure of ovaries as compared
to equal caliber.
The prognostic criteria of efficiency of the use of hormonal correction for teenagers with PCOS
is: diminishing of volume of ovaries to ≤10 cm3, decline of luteinizing hormone ≤1 IU/l, increase of
level of testosteron-estradiol binding globulin ˃81 pmol/l.
Conclusions. Findings allowed scientifically to ground the necessity of improvement of algorithm
of diagnostic and treatment-and-prophylactic measures for girls with PCOS in a pubertal period.
The algorithm of diagnostic and treatment-and-prophylactic measures is improved and inculcated
for the girls of pubertal period with PCOS, which gives a right to recommend him in a practical
health protection to us.