A role of age of patients is in the estimation of efficiency of assisted reproductive technologies at the combined forms of infertility

Abstract

DOI: 10.52705/2788-6190-2024-01-14
UDC 618.17-02:618.177-089.888.11

The objective: to learn the role of age of women and men in the estimation of efficiency of
assisted reproductive technologies (ART) at the combined forms of infertility.
Materials and methods. 70 matrimonial pair of reproductive age, which made the followings groups, were
inspected: basic (n=30), comparison (n=30) and control (n=10). In the complex of the conducted researches
were included clinical, echographic, endocrinology, morphological, statistical and immunological which included
determination of level of cytokines in a follicle liquid the method of the multipxleed analysis of albumens.
Results. Findings testify that strengthening of secretion in the ovary of прозапальних cytokines can
be one of mechanisms of unfavorable influence of stimulation of ovaries of gonadotropin on an oocyte.
It is presently foreseen that stimulation of ovaries, its modes influence on «quality» of oocyte,
potency of him to the impregnation and rates of early development of embryo. A negative role
high concentrations can play in blood of estradiol, and also pharmacological preparations, which
are used during stimulation of ovaries (gonadotropins, agonists and antagonists of gonadotropinreleasing
hormone), and also eyelids of patients.
The got results were confirmed by present fundamental pictures that co-operation between an
oocyte and somatic cages of ovary is critical for normal motion of oogenesis, impregnation and
early development of embryo, especially for the patients of older age.
Conclusions. To informing clinical-and-anamnestic and hormonal factors which determine the result of cycle
of ART for the patients of reproductive age with the combined forms of infertility, take: age of sick; index of
mass of body; presence pipe peritoneal factor of infertility; a level of free testosterone is in blood; a table of
contents of progesterone is in blood on 20–22 days of menstrual cycle, and also determination in the follicle
liquid of ovaries of cytokines. By us the rotined role of age of patients in the estimation of feicfiency of ART.