Modern aspects of early diagnostics of violations in the system mother­placenta­fetus

Abstract

DOI: 10.52705/2788-6190-2024-01-03
UDC 618.36-008.64-07-08

The objective: to develop the modern method of early diagnostics of heavy forms of placenta
disfunction.
Materials and methods. For realization put purpose, taking into account the developed
prognostic scale of heavy forms of placenta disfunction, there was the formed group of
supervision, which consists of 100 expectant mothers which in the terms of 18-24 weeks and
28-38 weeks gestation the conducted determination in blood of content of markers of endothelial
disfunction. Taking into account clinical motion of pregnancy, from 100 women two groups of
comparison were formed: I a group was made by 50 women with placenta disfunction; II group
– 50 women with placenta disfunction in combination with preeclampsia and by extragenital
pathology. A control group (III group) was made 30 healthy expectant mothers. In the II group
of comparison of preeclampsia diagnosed in 100% supervisions (mild severity – in 88,0%
pregnant and moderate severity – in 12,0%).
Results. The got results allowed nosotropic to ground including of the developed criteria of
placenta disfunction and degree of severity, together with an ultrasonic constituent, in the
diagnostic of this complication of pregnancy program with the purpose of increase of its
exactness. Results of early diagnostics of placenta disfunction and estimation of degree of
severity during pregnancy, based on the laboratory and ultrasonic testing (modified scale), in
comparison with the histological verified diagnosis rotined that placenta disfunction correctly
diagnosed in 91% supervisions, uncoincidences was 9%. The analysis of coincidence of clinical
and histological diagnoses at the heavy forms of placenta disfunction rotined an increase to
exactness of diagnostics at the use of the modified scale on 39,5% as compared to the use of
scale, based only on echographic criteria.
Conclusions. The results of the conducted researches testify that the clinical algorithm of
conduct of expectant mothers of risk group developed on the basis of evaluation diagnostic
scale (ultrasonic and laboratory testing) is promoted by exactness of diagnostics of placenta
disfunction on 26,1%, it heavy forms on 39,5%, instrumental in the choice of adequate obstetric
tactic, to the improvement of perinatal results at the heavy forms of placenta disfunction on
60%. The got results allow to recommend the method of early diagnostics of heavy forms of
placenta disfunction in a practical health protection.