Morphological characteristics of the influence in women of the high­risk group for the development of major obstetrical syndromes after pregraduate preparation

Authors

  • Nataliya Lemish Uzhhorod National University

Keywords:

pregnancy, women, major obstetric syndromes, fetoplacental complex, placental insufficiency, litter pathomorphology

Abstract

DOI: 10.52705/2788-6190-2024-02-01
УДК 618.3-008.6-06:618.36-039:576.31]-07-08

The objective: to determine the morphological and histological features of litters in women from
the high-risk group for the development of major obstetric syndromes (MОS), who received a
developed set of preventive measures.
Materials and methods. A prospective statistical analysis of the morpho-histometric features
of the litter was conducted. The main group (MG) of the study – 30 litters from women from the
high-risk group for the development of MОS, who received prevention and a complex of medical
and social measures at all stages of observation according to the algorithm developed by us,
the comparison group (CG) – 20 litters from women at high risk for development of MОS, in
which management tactics before and during pregnancy were carried out according to generally
accepted methods. Macroscopic and microscopic examination of the droppings was carried out
in accordance with the standard description protocol and modern research requirements (order
of the Ministry of Health of Ukraine «On the improvement of the children’s patho-anatomical
service» dated August 19, 2004, No. 417). Statistical processing of research results was carried
out using standard Microsoft Excel 5.0 and Statistica 6.0 programs.
Results. During the histological examination of placentas from OG women, a certain spectrum of
pathomorphological changes was revealed: manifestations of compensatory processes prevailed
and a significantly lower severity of pathological changes was noted. Pathological changes were
expressed in the thickening and defibrillation of the basal membranes with the deposition of
amorphous and fibrinoid substance between them, in some medium-sized vessels thrombi were
detected with the subsequent deposition of calcium and compaction of the surrounding placental
tissue. Focal relative immaturity of the placenta was noted, which was characterized by uneven
maturation of cotyledons in the form of variants of hypovascularized villi and delayed structural
and functional specialization of the syncytiotrophoblast. there was mainly a morphological picture
characteristic of the initial form of chronic placental insufficiency. Placental-fetal coefficient (PPC)
in OG women was probably higher than in GP women and was 0.17, against 0.15.
The research was conducted according to principles of Declaration of Helsinki Protocol of research
was proved by local ethical committee, mentioned in institution’s work. A informed sonsennt was
collected in order to carry out the research. The author is stating no conflict of interests is declared.
Conclusions. Morphological and histological studies of the litters of women from the high-risk
group for the development of MОS, who received complex correction of maladaptive disorders
in the fetoplacental complex, at all stages of observation, demonstrated that they include all the
structural mechanisms of placenta adaptation, which allow preserving the morphometric and
diffusion indicators of the villous trees at the level of sustainable compensation, which is the most
important adaptive means that allows maintaining the viability of the fetus.

Author Biography

Nataliya Lemish, Uzhhorod National University

Ph.D., docent, Department of obstetrics and gynecology, medical faculty, SHEI «Uzhgorod national university»

Published

04.07.2024

How to Cite

1.
Леміш Н. Morphological characteristics of the influence in women of the high­risk group for the development of major obstetrical syndromes after pregraduate preparation. par [Internet]. 2024 Jul. 4 [cited 2024 Jul. 15];4(2):7-15. Available from: http://par.org.ua/index.php/par/article/view/178