Influence of the combined pathology of uterus and mammary glands is on the reproductive function of women

Abstract

DOI: 10.52705/2788-6190-2024-02-03
УДК 618.17/.5-02:618.145

The objective: decline of frequency of violations of reproductive function for women with the
combined pathology of uterus and mammary glands on the basis of study of new aspects of
pathogeny of infertility, and also improvement and introduction of algorithm of diagnostic and
treatment-and-prophylactic measures depending on the variants of the combined pathology of
uterus and mammary glands.
Materials and methods. The basic form of pathology of mammary glands, which is studied, was
diffuse dysplasia of mammary glands. To the variants which are studied, of bening pathology of uterus
we took the leiomyoma of uterus and adenomiosis. A leiomyoma of uterus was small sizes (to 12
weeks pregnancies) of intramural and subserosal localization. Adenomiosis was key or diffuse form
of I-II of degree. Treatment of infertility all patients had conducted by the use of methods of assisted
reproductive technologies. A 1 group was made by 90 women from diffuse dysplasia of mammary
glands. Among them three sub-groups of women were selected taking into account the presence of
concomitant genital pathology. In the complex of the conducted researches were included clinical,
echographic, doppler, cardiotocographic, morphological, endocrinology, biochemical and statistical.
Results. Presence only of bening dysplasia of mammary glands does not influence on the state of
ovarian reserve, attachment of adenomiosis and leiomyoma significantly reduces ovarian reserve,
which is confirmed by decrease of volume of ovaries, number of antral follicles, content of folliclestimulating
hormone, inhibin B and to the Antimüllerian hormone. Efficiency of the programs
of assisted reproductive technologies for women with the combined pathology of uterus and
mammary glands does not depend on application of different charts of stimulation of ovaries, use
of assisted hatching, but depends on the state of the state of ovarian reserve and timely use of
oocytes of donor. Total efficiency of treatment of infertility for women with of bening dysplasia of
mammary glands is 53,3%; at combination from adenomiosisом – 33,3% and with a leiomyoma
– 30,0% respectively.
Conclusions. As results of the conducted researches, use of the improved algorithm of treatmentand-
prophylactic measures rotined for women with diffuse dysplasia of mammary glands in
combination with a leiomyoma and adenomiosisом allows significantly to promote efficiency of
treatment of infertility for the women of group of high risk.