An estimation of efficiency of assisted reproductive technologies is at the combined forms of infertility taking into account age of patients

Authors

  • Andrey Shchedrov Shupyk National Healthcare University of Ukraine

Keywords:

assisted reproductive technologies, combined forms of infertility, age of patients, efficiency

Abstract

DOI: 10.52705/2788-6190-2024-03.1-18
UDC 618.17-02:618.177-089.888.11

The objective: to learn the role of age of patients in the estimation of efficiency of assisted
reproductive technologies at the combined forms of infertility.
Materials and methods. By us 70 women of reproductive age, which made the followings groups,
were inspected: basic (n=30), comparison (n=30) and control (n=10). Criteria of exception for a
basic group and group of comparison were general: hyper- and hypogonadal гovarian insufficiency;
a delete of one or both ovaries is in anamnesis; heavy degree of asthenoeratozoospermia,
azoospermia only reason of infertility is a masculine factor; obesity of II–III of degree.
In the complex of the conducted researches were included clinical, echographic, endocrinology,
morphological, statistical and immunological methods which included determination of level of
cytokines in a follicle liquid the method of the multiplexed analysis of albumens.
Results. It is got by us results testify that with the increase of age of patients appropriately goes
down amount of growings follicles (Rс=-0,32; р<0,05); ovaries of oocytes (Rс=-0,33; р<0,01)
got during puncture, including mature (Rс=-0,31; р<0,05). It specifies on the decline of activity of
processes of follicculo- and oogenesis, frequency of offensive of pregnancy with the increase of
age of women. These processes are conditioned morpho-functional by the changes of ovaries for
the women of senior age, by the decline of them ovarian reserve, by the increase of frequency of
aneuploidy of oocytes, which can appear one of reasons of low frequency of implantation.
Except for the physiology increase of frequency of elimination of primordial follicles in senior
reproductive age, by factors which result in the decline of efficiency of gonadotropic stimulation of
ovaries for the inspected patients, there could be concomitant gynaecological diseases (chronic
salpingo-oophoritis, external genital endometriosis), carried operative interferences on the organs
of the reproductive system.
Conclusions. The results of the conducted researches testify that to informing clinical-andanamnestic
and hormonal factors which determine the result of cycle of assisted reproductive
technologies for the patients of reproductive age with the combined forms of infertility, take: age of patient; body index mass; presence tubo-peritoneal factor of infertility; a level of free testosterone
is in blood; a table of contents of progesterone is in blood on 20–22 days of menstrual cycle, and
also determination in the follicle liquid of ovaries of cytokines.
By us the rotined role of age of patients in the estimation of efficiency of assisted reproductive
technologies.

Author Biography

Andrey Shchedrov , Shupyk National Healthcare University of Ukraine

candidate of medical sciences, associate professor, Department of
obstetrics, gynaecology, oncogynaecology and endoscopy

Published

13.10.2024

How to Cite

1.
Щедров А. An estimation of efficiency of assisted reproductive technologies is at the combined forms of infertility taking into account age of patients. par [Internet]. 2024 Oct. 13 [cited 2024 Nov. 11];4(3-1):127-33. Available from: http://par.org.ua/index.php/par/article/view/222