The women of reproductive age have features of pathogeny of hyperproliferative processes of uterus and mammary glands

Abstract

DOI: 10.52705/2788-6190-2025-02.2-07
УДК 618.19:618.14-002.18-007.61-092-039

The objective: to estimate clinical-and-endocrinological features of hyperproliferative processes of uterus and mammary glands for the women of reproductive age.
Materials and methods. In research the included women of reproductive age are with the hyperplastic processes of endo – and myometrium and 30 healthy women which did not have pathology of endo – and myometrium (control group). A basic group was made 90 patients which parted on 3 sub-groups: in a 1th sub-group patients are plugged with combination of leiomyoma of uterus and adenomyosis (n = 30); in a 2th sub-group are patients with the leiomyoma of uterus in combination with the hyperplastic processes of endometrium (n = 30); in a 3th sub-group are patients which have combination of leiomyoma of uterus, adenomyosis and hyperplasia of endometrium (n = 30). The group of comparison was made by 90 patients which parted on 3 subgroups: sub group A are patients with the isolated leiomyoma of uterus (n = 30); sub-group B – with isolated adenomyosis (n = 30); sub-group C – with the isolated hyperplastic processes of endometrium (n = 30). To the complex of the conducted researches clinical, laboratory instrumental and statistical methods were included.
Results. The characteristics of the remodeling process of the intercellular matrix in the myometrium were analyzed. The function of remodeling of extracellular matrix is executed by extracellular dependent for zinc of endopeptidase – matrix metalloproteinase, and them tissue inhibitors. The relative area of expression of matrix metalloproteinase-9 in a basic group made 4,76 ± 0,42%, that in 2 times more than in the group of comparison, where this index was even 2,23 ± 0,19% (p < 0,05). The absorbancy of expression of matrix metalloproteinase-9 in a basic group made 3,51 ± 0,33 conditional units, that in 3 times more than in the group of comparison – 1,17 ± 0,23 conditional units (p < 0,05). The relative area of expression of tissue inhibitors of matrix metalloproteinase-1 in a basic group made 2,11 ± 0,14%, that on 48% less than, than in the group of comparison, where this index was evened 3,12 ± 0,31% (p < 0,05 – as compared to an index in the group of comparison). The absorbancy of expression of tissue inhibitors of matrix metalloproteinase-1 in a basic group made 2,02 ± 0,21 conditional units, and in the group of comparison – there are 2,38 ± 0,29
conditional units.
Conclusions. In pathogeny of the combined forms of high quality hyperplastic diseases of uterus in reproductive age play a leading role morpho-functional the changes of intact myometrium - for certain the higher level of expression of receptors of estrogen decline of level of expression of receptors of progesterone, high expression of factor of growth of endothelia of vessels of VEGF. Findings must be taken into account at development of algorithm of diagnostic and treatment-andprophylactic measures.