Algorithm of prognostication and preclinical diagnostics of proliferative processes of endometrium for women different age

Abstract

DOI: 10.52705/2788-6190-2025-4-11
УДК 618.14-031:611.64]-007.61-07-037

The objective: to develop the algorithm of prognostication and preclinical diagnostics of proliferative processes of endometrium for women different age.
Materials and methods. All patients which entered in research parted on three groups of comparison depending on character of pathology of endometrium: I a group is 138 patients with the of benigh hyperplastic processes of endometrium; The II group is 509 patients with the cancer of endometrium part on three sub-groups: IIa – 200 patients from highly differentiated adenocarcinoma; IIb – 171 sick with moderately differentiated adenocarcinoma; IIc – 138 patients with low-grade differentiated adenocarcinoma; The III group is 67 patients without pathology of endometrium. The laboratory methods of researches were included by biochemical, endocrinology and immunological indexes. For prognostication the calculation of indexes of relative risk was conducted in obedience to a method, accepted at epidemiology researches on a method «case-control». For the estimation of prognostical methods (echography, doppler, hysteroscopy) calculated and analysed the followings descriptions: sensitiveness, specificity, value of positive result which provides for, value of negative result which provides for, prognostical exactness.
Results. The got results allow to assert that most investigational by us nicotinamide adenine nucleotide phosphate-dependent enzymes suitable as markers of metabolism. Enzymatic activity, determined in peripheral blood of patients of endometrial cancer of different degree differentiation, in a substantial measure represents character of metabolic changes in tumour tissue. The pair of indexes («tissue–blood») of the most studied enzymes positively correlate between itself with the level of authenticity not less than 99%. Determination of activity of nicotinamide adenine nucleotide-dependent malate dehydrogenase will allow with the high degree of authenticity to foresee the presence of low-grade differentiated adenocarcinoma of endometrium on the preoperated stage, for the adequate planning of volume of operative treatment and conduct of subsequent ad’juvant therapy which substantially will improve the results of therapy and will reduce the indexes of death rate.
Conclusions. The results of the conducted researches allow to complement the new scientific questions of pathogenesis of proliferative processes of endometrium and offer the algorithm of prognostication and preclinical diagnostics of proliferative processes of endometrium for women different age.