The pregnant have features of hormonal status with uterine fibroids and them new­born

Abstract

DOI: 10.52705/2788-6190-2025-4-01
УДК 618.14-006.36-06/618.3:616-053.31]-039:612.018

The objective: to estimate the features of hormonal status for pregnant with uterine fibroids and them new-born.
Materials and methods. The conducted analysis is 299 variable maps and histories of births of patients, delivered by caesarean section in a term 38–40 weeks, including 235 – with a multiple uterine fibroids. In connection with the put purpose groups were created: I a group (n = 101) is patients and them new-born, motion of pregnancy of which is associated with a multiple uterine
fibroids, with the sizes of most node there is more than 5 sm; II group (n = 134) is patients and them new-born, motion of pregnancy of which is associated with a multiple uterine fibroids, with the sizes of most node there is less than 5 sm; III group (n = 64) is patients without uterine fibroids, delivered by caesarean section, and them new-born. Researches of level of hormones conducted the method of immunoenzyme analysis on an automatic immunoenzyme analyzer. Determination of level of estriol free, estradiol, prolactin, progesterone, thyrotropic hormone, thyroxine, triiodo-thyronine, cortisol, dehydroepiandrosteronesulfat it was conducted a with the use of standard test system.
Results. By us found out tendencies to the decline of progesterone, testosterone, estriol and estradiol in blood in new-born from mothers with uterine fibroids as compared to a III group, however findings were within the limits of normative values and reliable differences by us it is not discovered (p > 0,05). In the that test of blood we learned the level of hormones of thyroid and adrenal glands of mothers and them new-born I and III groups. In I group the level of triiodo-thyronine made, on the average, 18,27 ± 7,9 nmol/l, in III – 25,7 ± 14,01 nmol/l remained within the limits of norm. Will mark that this index on 27% was below in I group, however reliable differences are (p > 0,05). Thyroxine free at blood of patients I group, on the average, there was 12,12±2,15 pmol/l, in III – 11,49±2,72 pmol/l were in normative limits. The level of thyrotropic hormone for patients I group, on the average, made 2,02±0,84 μIO/ml, in the III – 2,24±1,6 μIO/ml. This index was in normal physiology values. Reliable differences, at the study of hormones of thyroid in blood of mothers I and III groups it is not discovered by us, without regard to tendencies to the decline of level of triiodo-thyronine for patients with a uterine fibroids (p>0,05).
Conclusions. Without regard to absence of reliable differences between groups, for women with a uterine fibroids the level of such hormones as estriol and estradiol was below (on 27% and 36% respectively). The same tendency is marked and in the indexes of blood new-born: on 18% reduced estriol and on a 16,5% estradiol. At the analysis of levels of testosterone found out the decline of this index on 16%, prolactin on 27% for women with uterine fibroids. In new-born the level of testosterone was below on 28% in I group. For patients with a uterine fibroids the increase of levels of thyroxine, decline of triiodo-thyronine and thyrotropic hormone was marked, but reliable differences were not (p>0,05). In new-born levels of triiodo-thyronine and thyrotropic hormone were a bit higher, the level of thyroxine тироксину lower, than in new-born III groups. Similarly in blood for patients with a uterine fibroids found out a tendency to the increase of level of cortisol, however unreliable differences are. Findings must be taken into account at development of algorithm of diagnostic and treatment-and-prophylactic measures.