Role of infectious pathogens which is selected from a cervical canal and biopsies of operating material, in genesis of hyperplastic processes of uterus for women different age

Abstract

DOI: 10.52705/2788-6190-2026-01-10
УДК 618.4-007.6-022-092

The objective: to set the role of infectious pathogens which is selected from a cervical canal and biopsies of operating material, in genesis of hyperplastic processes of uterus for women different age.
Materials and methods. For the decision of the put purpose 397 women were inspected different age. Plugging criteria are in research: presence of the combined hyperplastic processes of uterus - two and greater disease (endometrial hyperplasia, uterine fibroids and adenomyosis), verified morphologically, fertility age (18–45 years), absence in anamnesis of immunosuppressive therapy (6 months prior to entering into permanent establishment). On the basis of clinical motion of disease, information of genital status and pathomorphological conclusion the followings groups were formed: I a group was made 113 women with the hyperplastic process of endometrium and uterine fibroids, II group – 112 women with the hyperplastic process of endometrium and adenomyosis; III group – 101 patient with combination of three diseases - adenomyosis, uterine fibroids and endometrial hyperplasia. Foundation for plugging in the group of comparison was a presence exceptionally endometrial hyperplasia (without combination with uterine fibroids and adenomyosis, IV group) (information retrospective inspection, n = 71). The control V group was made by 90 women from a contingent gynaecological of healthy. To the complex of the conducted researches were included clinical, echographic, microbiological and statistical methods.
Results. Inspection of patients on all spectrum of exciters of sexually transmitted infections and conditionally pathogenic microorganisms of genital tract showed, that M. hominis was the unique etiologic agent in 80 % standards of mutated strain, in clinical isolates in default of mutations of monoinfecting of M. hominis it is marked at 2,8 time rarer (28,6 %). Found out cross-correlation copulas – positive – hyperplastic diseases of uterus with the level of CFU/ml (r = + 0,39; p = 0,006), and also with the strains of mutants of M hominis (r = +0,36; p = 0,012). From positions of confession of viability only heterogeneous population of microorganisms, presence of strains of mutants of M. hominis adds genetic heterogeneity to this population, consequently, firmness and potential for subsequent existence. The presence of direct cross-correlation connections between the level of CFU and frequency of hyperplastic processes confirms higher pathogenicity of strains of mutants of M. hominis, foreseeing their role as cofactors of diseases.
Conclusions. It is set pathomorphological researches of operating biopsies (endometrium, uterine fibroids and foci of adenomyosis), that for patients with combination of endometrial hyperplasia with a uterine fibroids and adenomyosis is: signs of chronic inflammatory process are in tissue of uterus; infecting of tissue of endometrium and myometrium conditionally pathogenic microorganisms; staggered by them not only mucus membrane but also myocytes; presence in 45,1 % strains of mutants of Mycoplasma of hominis; correlation of hyperplastic diseases of uterus is with the strains of mutants of M. hominis. The got results allow to examine infectious pathogens as cofactors of hyperplastic processes uteruses which are nosotropic related to the representatives of flora of lower departments of genital tract and take part in realization of inflammatory process.