The pregnant of group of infectious risk have correlative relationships between different proteins

Abstract

DOI: 10.52705/2788-6190-2025-02.2-02
УДК 618.3-022.7-06:612.015.348:311.14

The objective: to set correlative relationships between different proteins for pregnant of group of infectious risk.
Materials and methods. To achieve this goal, 5 groups of patients were formed. In a 1 group entered 111 pregnant with the presence of antibodies of class of G to Chlamydia of trachomatis in a title 1:5–1:40, without the clinical displays of disease in mothers, with the signs of the intrauterine infecting from the term of pregnancy 18–20 weeks, without antibacterial therapy during pregnancy,
inspected in a term 13–24 weeks and in 38–40 weeks of gestation. 2 groups were presented 45 pregnant with the presence of high-avidity antibodies of class of G to Herpes of simplex 1,2 without the clinical displays of which or disease in mothers, with the signs of the intrauterine infecting from the term of pregnancy 18–20 weeks (polyhydramnios, fetal growth retardation, thickening of placenta, suspension in amniotic fluid and ets), without medicinal therapy during pregnancy, inspected in a term 38–40 weeks gestation. 3 groups were made 45 pregnant with the presence of Candida of albicans 104–106 CFU /l, without the clinical displays of infectious disease in mothers, with the signs of the intrauterine infecting from the term of pregnancy of 18–20 weeks (polyhydramnios, fetal growth retardation, thickening of placenta, suspension in amniotic fluid and ets), without medicinal therapy during pregnancy, inspected in a term 38–40 weeks gestation. Delivery through natural birth canal in the term of gestation 38–40 weeks. 4 groups consisted of 43 pregnant from Staphylococcus of aureus, without the clinical displays of infectious disease in mothers, with the signs of the intrauterine infecting from the term of pregnancy 18-20 weeks (polyhydramnios, fetal growth retardation, thickening of placenta, suspension in amniotic fluid and ets), without medicinal therapy during pregnancy, inspected in a term 38–40 weeks gestation. Delivery through natural birth canal in the term of gestation 38–40 weeks. A to 5 group entered 157 pregnant transmitters of exciters of mixt-infection, without the clinical displays of infectious disease during all pregnancy, with
the signs of the intrauterine infecting from the term of pregnancy 18–20 weeks (polyhydramnios, fetal growth retardation, thickening of placenta, suspension in amniotic fluid and ets), without antibacterial therapy during pregnancy, inspected in a term 38–40 weeks gestation. Delivery through natural birth canal in the term of gestation 38–40 weeks. To the complex of the conducted researches were included clinical, echographic, laboratory, microbiological and statistical methods.
Results. At presence of high-avidity of IgG of antibodies to Herpes of simplex1,2, the levels of lactoferrin were back associate with concentrations alpha-1-antitrypsin and, aught trophoblastic beta-globulin, and also directly with content pregnancy associated alpha-2-glycoprotein. Last interestingly enough, as pregnancy associated alpha-2-glycoprotein from one side, assists to development of pregnancy, and from other – creates favourable terms for distribution of pathology without the expressed displays of immune answer and proper inflammatory reaction due to the immunosuppressive properties. Pays attention on itself, that in a norm levels pregnancy associated alpha-2-glycoprotein associate only from alpha-2-by a macroglobulin (straight) and alpha-1-antitrypsin (back) while at presence of antibodies to Herpes simplex orientation of connection from alpha-1-antitrypsin changes on an opposite side. Also direct connection appears with the whey concentrations of the pregnancy associated protein A also tendency to reverse dependence on the trophoblastic beta-globulin. A that tendency comes to light at the transmitter of Staphylococcus of aureus, and at presence of IgG to Chlamydia of trachomatis it becomes reliable and direct. At the transmitter of Staphylococcus of aureus, that complicates pregnancy, as well as at presence of high-avidity of IgG of antibodies to Herpes of simplex1,2, level pregnancy associated alpha-2-glycoprotein depends on content of other reserve representative of family of macroglobulins (pregnancy associated protein A). At the transmitter of Candida of albicans, as well as at presence of IgG of antibodies to Chlamydia of trachomatis in a title 1:5–1:40 there is dependence on the level of alpha-fetoprotein, but not reverse, but line.
Conclusions. The analysis of correlative relationships allowed to show, that detected before changes of concentrations of whey indexes were not casual, but in a great deal associate, that confirms participating of immunoregulatory albumens and albumens of pregnancy in development of pathological processes at the transmitter of exciters perinatal the meaningful hidden infections
and grounds the necessity of their including for a general prognostical algorithm which takes into account different indexes and that promotes them total prognostical value.