Women have features of metabolism of estrogen and state of mammary glands after hysterectomy

Abstract

DOI: 10.52705/2788-6190-2025-02.2-06
УДК 618.18-039:618.14-089.85-089.168.1

The objective: to estimate the features of metabolism of estrogen and state of mammary glands for women after hysterectomy.
Materials and methods. By us it was inspected 156 patients by a uterine fibroids, which is a basic certificate for implementation of hysterectomy. All patients with a uterine fibroids depending on age parted on 2 clinical groups: a 1 group was 67 patients which was added hysterectomy in late reproductive age (36–44 years, on the average in 40,9±0,9 year); to 2 groups entered 89 patients which are operated in premenopause (45–47 years, on the average in 45,9±0,2 year). A control group was made 20 practically healthy women of analogical age. To the complex of the conducted researches clinical, laboratory, instrumental and statistical methods were included.
Results. Level of correlation of investigated metabolites for patients with the certain size of uterine fibroids in late reproductive age and in premenopause, was comparable and did not have of principle differences. The in addition, expressed violations of metabolism of estrogen are established for patients with combination of uterine fibroids, hyperplasia of endometrium and adenomyosis – in 60,0% supervisions coefficient 2-hydroxyestrone /16а-hydroxyestrone was < 1. A study was conducted of mammary glands for the women of basic groups depending on the indexes of metabolism of estrogen in urine. For 3 patients with correlation of metabolites estrogen more than 1,5 the established absence of changes in mammary glands. At oscillation of this index within the limits of 1,0–1,5 any pathology of mammary glands to the conduct of hysterectomy absented in 20,8% patients. At correlation 2-hydroxyestrone /16а-hydroxyestrone less than 1 different forms fibro-cystic mastopathy is diagnosed for all patients.
Conclusions. Patients with uterine fibroids which the conduct of hysterectomy is foreseen with the maintainance of appendages of uterus are included in the group of enhanceable risk in relation to to the origin and progress of diseases of mammary glands in a postoperative period. Metabolism of estrogen for patients by a uterine fibroids to and after the conduct of hysterectomy, in comparing to the healthy women, is characterized by enhanceable education metabolically active 16-а-hydroxyestrone. Findings must be taken into account at development of algorithm of diagnostic, treatment-andprophylactic and rehabilitation measures.