Assessment of D-status in women at risk for premature birth

Authors

  • Vira Pyrohova Danylo Halytskyi Lviv National Medical University
  • Oksana Laba Danylo Halytsky Lviv National Medical University

Keywords:

premature birth, risk factors of premature birth, vitamin D deficiency, cholecalciferol

Abstract

DOI: 10.52705/2788-6190-2022-04-3
УДК 618.396+577.161.22

Vitamin D deficiency is one of the most common vitamin deficiencies worldwide. An important factor
that has been intensively investigated in recent years is the prevalence of vitamin D deficiency in the
pregnant population and the effect of vitamin D deficiency on the course of pregnancy.
The objective: work was to assess the D-status of pregnant women at risk of premature birth

Materials and methods. The studied cohort consisted of 170 women, of which 73 were pregnant
women with a threat of premature birth at 23–32 weeks of gestation (group I); 77 patients with
risk factors for premature birth (II group) and 20 conditionally healthy pregnant women at 37-
39 weeks’ gestation (control group). The level of 25(OH)D in blood serum was determined by
an immunochemical method with chemiluminescence detection (CMIA) (test systems ABBOT
Diagnostics, USA). The D-status was assessed according to the recommendations of international
experts, according to which the norm was the level of 25(OH)D > 30 ng/ml, the suboptimal level –
20–29.9 ng/ml, the moderate deficiency 10–19.9 ng/ml , severe deficiency < 10 ng/ml.

Results. The average age of the patients was 28.4±3.5 years. Lack and deficiency of vitamin D
among patients of the examined cohort accounted for 79.4% of cases. The highest frequency of
vitamin D supply (65.0%) was observed among patients of the control group at an average level
of 25(OH)D in blood serum of 36.7±3.5 ng/ml. Vitamin D deficiency occurred more often (41.6%)
in patients of the II group with risk factors for preterm birth, while vitamin D deficiency was most
common (53.4%) among pregnant women at risk of preterm birth.

Conclusion. The conducted study showed a significant prevalence of lack and deficiency of
vitamin D among patients with the threat and risk factors of premature birth. Given the limited
sample, it is premature to draw a conclusion regarding the relationship between vitamin deficiency
and the development of premature birth, which justifies the need for further research.

Author Biographies

Vira Pyrohova, Danylo Halytskyi Lviv National Medical University

Doctor of Medical Science, Professor, Head of the department of obstetrics, gynecology and perinatology Faculty of postgraduate education Danylo Halytskyi Lviv National Medical University; tel.: (050) 581-94-48.

Oksana Laba, Danylo Halytsky Lviv National Medical University

Assistant of the Department of Obstetrics, Gynecology and Perinatology Faculty of postgraduate education Danylo Halytsky Lviv National Medical University; tel.: (097) 306-13-87.

Published

22.01.2023

How to Cite

1.
Пирогова В, Лаба О. Assessment of D-status in women at risk for premature birth. par [Internet]. 2023 Jan. 22 [cited 2023 Jan. 31];2(4):23-9. Available from: http://par.org.ua/index.php/par/article/view/93