Functional the state of thyroid gland for women with the plural hyperplastic processes of organs of the reproductive system

Abstract

DOI: 10.52705/2788-6190-2025-02.2-08
УДК 618.1-018-007.6-06:616.441-036

The objective: to estimate the functional state of thyroid gland for women with the plural hyperplastic processes of organs of the reproductive system.
Materials and methods. For the decision of the put purpose 74 women are inspected. To the basic group entered 54 patients with two and by more hyperplastic processes of organs of the reproductive system (uterine fibroids, hyperplasia and endometrial polyps, adenomyosis, external genital endometriosis, fibro-cystic mastopathia). A control group was made by 20 women from ovulatory menstrual cycle, middle duration of 28,4 ± 0,8 day. Except for clinical and echographic methods, for research to the function of ovaries determined maintenance in blood of estradiol on 5-7 day of menstrual cycle, prgesterne on 20–24 days of menstrual cycle. For research to the function of thyroid gland conducted determination of maintenance in blood of free thyroxine and thyrotropic hormone. In blood of all women determined the presence of antibodies to thyroperoxidase.
Results. 22 women (40,7 ± 7,0%) with the plural hyperplastic processes of organs of the reproductive system had diseases of thyroid gland. The diffuse untoxic goitre of I and II degree was found out in 6 patients (11,1 ± 1,3%), diffusely nodular untoxic goitre of I and II degree — also in 6 women of basic group (11,1 ± 1,3%). A nodular goitre found out in 7 patients (13,0 ± 1,6%). Diffuse and diffusely nodlar untoxic goitre discovered in 4 from 9 (44,4 ± 4,6%) women with a presence in the structure of plural hyperplastc processes of organs of the reproductive system of external genital endometriosis, in 10 from 46 (21,7 ± 2,1%) women with a uterine fibroids, in three from 15 (20,0 ± 1,3%) patients with hyperplasia and endometrial polyps and in 4 from 19 (21,0 ± 2,3%) patients from adenomyosis. Frequency diffuse and diffusely nodular untoxic goitre for women from fibro-cystic mastopathia made 25,0 ± 2,2% (12 from 48 patients). Nodular formations of thyroid gland were found out in two from 9 (22,2 ± 1,9%) women with external genital endometriosis, in 5 from 46 (10,9 ± 1,6%) patients with a presence in the structure of diseases of uterine fibroids, two from 19 (10,5 ± 1,0%) patients from adenomyosis and 5 from 48 (10,4 ± 1,4%) women from fibro-cystic mastopathia.
Conclusions.The results of the conducted researches testify that in most women (94,4 ± 3,1%) with the plural hyperplastic processes of organs of the reproductive system the function of thyroid gland is not broken. The table of contents of free thyroxine in their blood does not differ from his level in blood of healthy women, which does not ground to bind development of proliferative diseases of organs of small pelvis and mammary glands to the parafunction of thyroid gland. Findings must be taken into account at development of algorithm of diagnostic and treatmentand-prophylactic.