Prophylaxis of miscarriage for women with pathology of cervix in anamnesis

Abstract

DOI: 10.52705/2788-6190-2022-04-2
УДК: 618.14 – 006.363:618.146:618,39] – 08 – 039.71

The objective: a decline of frequency of miscarriage for women with a leiomyoma and pathology
of cervix in anamnesis on the basis of study clinical-and-microbiological and endocrinological
features and development of complex prophylactic -and-treatment measures.

Materials and methods. On I the stage the studied features of motion of pregnancy, births,
post-natal and neonatal periods in 50 patients with the leiomyoma of uterus and pathology of
cervix in anamnesis, which got generally accepted complex prophylactic-and-treatment measures
(I basic group), for comparative description analogical parameters were studied in 50 obstetric
and somatically healthy primiparous (control group). On the II stage the clinical is conducted
and instrumental-laboratory estimation developed by us complex prophylactic-and-treatment
measures which was used to and during pregnancy, for 50 women with the leiomyoma of uterus
and pathology of cervix in anamnesis (II basic group).

Results. For women with a leiomyoma and pathology of cervix in I considerable frequency of threat
of miscarriage takes place the half of pregnancy – 72% by comparison to 8% in control (р<0,01),
thus a retrochorial haematoma arose up at localization of chorion in the projection of leiomyomatous
node 24% cases. More frequent among women I basic group took place early toxicosis 28%,
against 12% (р<0,05) in control. Such tendency was saved in the second half of pregnancy: threat
of late spontaneous abortion 24%, against 4% in a control group (р<0,01); placenta disfunction
48%, against 4% in a control group (р<0,01). Investigation of these pathological changes is an origin
of fetal distress in births – 24%, against 8% in a control group (р<0,05); premature removing layer by
layer of the normally located placenta – 8%, against 2% in a control group (р<0,05).
The indicated complications conduce to growth frequencies of operative delivery for women with
a leiomyoma and pathology of cervix, in particular, frequency of caesarian section grows to 64%
cases, against 14% supervisions in a control group (р<0,05).

Conclusions. Developed by us complex prophylactic-and-treatment measures with the use
on the pregravid stage of vegetable preparation from antiproliferative, by immuunomodulatory
activity, and beginning from the early terms of pregnancy of natural micronized progesterone,
donator nitric and local antiseptic oxide, that not influences on the normal microflora of vagina,
allows to reduce frequency of miscarriage and other obstetric and perinatal complications, but it is
instrumental in the improvement of results of delivery for women with a leiomyoma and pathology
of cervix in anamnesis.
Indicated positive changes take place on a background deceleration of rates of growth of
leiomyomatous nodes, absence of their degeneration, and also low to the percent of pathological
changes of cervix on a background the increase of colonization resistance of vagina.