Women have tactic of prognostication of placenta disfunction with the burdened genesial anamnesis

Abstract

DOI: 10.52705/2788-6190-2022-04-12
УДК 618.177-089.888.11-06:616-053.31-036.1

The objective: to develop tactic of prognostication of placenta disfunction for women with
the burdened genesial anamnesis – after auxiliary genesial technologies.

Materials and methods. А complex inspection is conducted 100 pregnant after auxiliary
genesial technologies and them new-born (basic group). Group to comparison made 50
women of analogical age, in which pregnancy came in natural way.
In the complex of the conducted researches were included clinical, echographic, doppler,
cariotocographic, endocrinological, morphological and statistical.

Results. Discovered by us interesting feature, women were divided into 3 types of activity
on force of expression of progesterone and estrogen receptors in endometrium and local
immunity – high expressive, medium expressive and low expressive. We analysed the
features of anamnesis of patients of every type.
Women, which fed a weakness to the hyperplastic syndrome as of high quality tumours of
uterus and ovaries, ferrous hyperplasia of endometrium with dysmenorrhea, entered in a
high expressive type (I group). As a result of immunohistochemistry high expression was
marked and progesterone and estrogen receptors, both in stroma and in glands +7, +8.
Medium expressive type (II group): junior women with non burden somatic anamnesis,
with a normal menstrual cycle. As a result of immunohistochemistry expression of
progesterone receptors in stroma made 5+, 6+, in the glands of 6+, 7+; estrogen from 4+
to 6+ and in stroma and in glands, that expression of progesterone receptors some higher
than естрогенових.
The patients of low expressive type (III group) were characterized by high-frequency of
civil marriages, early beginning of sexual life, frequent change of sexual partners, sickly,
irregular menstruations, high level of inflammatory diseases of organs of small pelvis,
chronic endometrial infection. For them there was characteristic more frequent primary
infertility by duration from 2 to 10 years. In this type expression of receptors was most low
(less than 4+), thus in two cases receptors absented quite.

Conclusions. It is set that most diagnostically meaningful in forming of primary placenta
insufficiency are indexes of reserve stock of ovaries of anti-mullerian hormone, ingibin-B
and enhanceable values of marker of placenta disfunction of TGF-pl. After auxiliary
genesial technologies the exposure of 3 types of activity of endometrium appeared the
leading nosotropic mechanism of development of placenta disfunction: high expressive,
medium expressive and low expressive.
The got results must be taken into account at development of algorithm of predictive and
diagnostic measures after auxiliary genesial technologies.