Married couples have reasons of miscarriage of pregnancy at infertility

Abstract

DOI: 10.52705/2788-6190-2026-01-14
УДК 618.39-06:618.177:616.697]-058.833

The objective: to find out reasons of miscarriage of pregnancy at infertility at married couples.
Materials and methods. We are conduct instantaneous transversal research which includes complex clinical-and-laboratory inspection 72 married couples with miscarriage of pregnancy in anamnesis (basic group). The group of comparison was presented 22 by married couples which became the parents of healthy children for period covered without the burdened reproductive anamnesis. To the complex of the conducted researches clinical, laboratory and instrumental methods were included.
Results. The anatomic features of uterus found out in 6 (20,7 %) women with sporadic abortion and 4 (9,3 %) women with usual abortion, р = 0,187. Chronic endometritis is morphologically verified for a 41 (95,3 %) woman with usual abortion and 22 (75,9 %) women with one involuntary abortion, р = 0,025. Thus on activity of inflammatory process of endometrium meaningful differences are not set statistically. At usual abortion of endometritis histological considered as nonactive in 26 (60,5 %) women, minimum degree of activity – in 9 (20,9 %), moderate degree of activity – in 6 (13,9 %), at one involuntary abortion of endometritis was nonactive in 16 (55,2 %) women, minimum active – in 4 (13,8 %), moderate degree of activity in 2 (6,9 %), р = 0,085. Hormonal violations are set in 15 (34,9 %) women with usual abortion and 11 (37,9 %) women with sporadic abortion, р = 0,808. A thrombophilia took place in 10 (34,5 %) women with one involuntary abortion and 17 (39,5 %) women with usual abortion, р = 0,805. Compatibility of the married couples for 2 and more discovered the antigens of the system HLA in 18 (41,9 %) married couples with usual abortion and 14 (48,3 %) couples with one involuntary abortion, compatibility for 3 and more set antigens at usual abortion for the 14 (32,6 %) married couples, at sporadic abortion – in 10 (34,5 %), р = 0,728. The variants of kariotype are certain in 6 (20,7 %) married couples with sporadic abortion and 6 (13,9 %) couples with usual abortion, р = 0,527. For a 21 (72,4 %) woman with sporadic abortion and 29 (67,4%) women with the usual miscarriage are set the combined reasons of gestational losses.
Conclusions. As a result of deep inspection it is not set statistically meaningful differences in the structure of reasons of gestational losses at sporadic abortion and usual miscarriage of pregnancy, except for chronic endometritis, which statistically meaningfully more frequent diagnosed for women with usual abortion.