Clinical­and­functional features of the system mother­placenta­fetus at a antenatal hypoxia with fetal losses

Abstract

DOI: 10.52705/2788-6190-2025-02.2-04
УДК 18.39-001.8-06:618.3/.36-07-039

The objective: to estimate clinical-and-functional features of the system mother-placenta-fetus at a antenatal hypoxia with fetal losses.
Materials and methods. A basic (1th) group was made by 55 cases of death of fetus from a antenatal hypoxia in terms of 23-40 weeks at a singleton pregnancy: 55 placentas and 52 fetuses (in 3 cases a section was not produced). These 55 the most difficult for diagnostics supervisions of antenatal death of fetus were included by us in a 1 group of research on the basis of the unspecified nosotropic role of placenta and not clear tanatofenesis, they were 52% all antenatal losses. Cases of antenatal death of the set etiology - with infectious fetopathy, by innate teratosiss, incompatible with a antenatal period, - from research eliminated, as well as multiple pregnancy. Three groups of comparing to birth living new-born, without regard to threatenings lives of fetus will become a draught pregnancies, formed on the basis of clinical estimation of weight of placenta dysfunction and result of pregnancy, – all investigational 46 placentas of new-born in terms of 25-40 weeks at a singleton pregnancy. To the complex of the conducted researches were included clinical, echographic, doppler, cardiotocographic and statistical.
Results. Obstetric-gynaecological anamnesis of pregnant with the antenatal hypoxia of fetus (n=55) was burdened by miscarriage of pregnancy with 1-4 involuntary abortions (in 11), 1-3 antenatal losses (in 7), postnatal death of new-born (in 6), gynaecological diseases of inflammatory and noninflammatory genesis: cervicitis and by a cervical ectopia (in 19), endometritis (in 6), adnexitis (in 11), urogenital infection (in 10), herpetic and by a cytomegalovirus infection (for 6 patients), primary and second infertility (in 6), cysts of ovaries, endometriosis and uterine fibroids (for 5 patients), by the anomaly of uterus (in 1), by a scar on an uterus after C-section (in 4), hyperandrogenism (in 4), by medical abortions from 1 to 5 (in 21). Pregnancy came after in vitro fertilization for a 1 patient. Pregnancy which made off antenatal death of fetus, in 26 accompanied by the threatened miscarriage, at one – isthmic cervical insufficiency. 43 pregnant in I–III trimesters got treatment concerning complications of pregnancy or basic disease, including 33 – stationary, 18 from them – with the repeated hospitalization. Antenatal death of fetus came on the prehospital stage in 19 pregnant. 36 fetuses perished in permanent establishment of antenatal, including 7 during the first days after hospitalization pregnant. Results of clinical blood nest (65), aggregogram (8), coagulograms (37), to the glycemic type (20) of pregnant 1 and 2 sub-groups were not had meaningful differences.
Conclusions. Conducted estimation clinical-and-functional features of the system motherplacenta-fetus at a antenatal hypoxia with fetal losses. The got results must be taken into account at development of algorithm of diagnostic and treatment-and-prophylactic measures.